Algernon’s Ifenprodil Background

Algernon's Ifenprodil Background

Ifenprodil is one of the drugs we have been investigating for repurposing as a lead candidate for the treatment of idiopathic pulmonary fibrosis (IPF), acute lung injury (ALI) and chronic cough. It is a generic Sanofi neurological drug developed in the 1970’s and is currently approved for use in South Korea and Japan:

  • We first investigated Ifenprodil for idiopathic pulmonary fibrosis (IPF), and it outperformed the world’s two leading treatments for the disease – Boehringer Ingelheim’s Nintedanib and Roche’s Pirfenidone – in a pre-clinical in vivo animal study, reducing fibrosis by 56% with statistical significance.

IPF Study Media Release

  • We additionally investigated Ifenprodil in a recent acute cough animal study where it outperformed Merck’s phase 3 drug Gefapixant by 110%.

Acute Cough Study Media Release

  • We are planning to conduct a phase 2 study in Australia for Ifenprodil for IPF and chronic cough and have now submitted for ethics approval. Chronic cough is a cough that is persistent in a person for 8 weeks.
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